Review of Clinical Pharmacology and Pharmacokinetics – International Edition 38(2): 197-204, doi: 10.61873/TOZB6842
Aripiprazole cognitive effects on attention deficit hyperactivity disorder (ADHD) in experimental mouse model
expand article infoHalima O. Qasim‡, Israa M. Jabber§, Sami M. Ahmed‡, Marwan Merkhan§
‡ Department of Pharmacy, Duhok Technical University, Duhok, Kurdistan, Iraq§ College of Pharmacy, University of Mosul, Mosul, Iraq
© Halima Qasim, Israa Jabber, Sami Ahmed, Marwan Merkhan.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Qasim HO, Jabber IM, Ahmed SM, Merkhan M (2024) Aripiprazole cognitive effects on attention deficit hyperactivity disorder (ADHD) in experimental mouse model. Review of Clinical Pharmacology and Pharmacokinetics – International Edition 38(2): 197-204. https://doi.org/10.61873/TOZB6842
Open Access
Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is one of children’s neurodevelopmental psychological disorders with ideal therapy obscure. Aripiprazole is an antipsychotic medication with a unique mechanism of action that enhances dopamine activity in the prefrontal cortex in turn it might executive function in ADHD patients. This study aimed to clarify the impact of aripiprazole on ADHD using a socially isolated (SI) mice model. Methods: In the current study we used early-life SI mice as models for ADHD and tested three different doses of aripiprazole on attention set-shifting performance. The socially Isolated mice are known to have impairment in attentional set-shifting. Socially housed and isolated reared mice across different doses of aripiprazole for each stage were cross-matched for comparison. Results: Socially isolated mice showed selective great deficits in interdimensional discriminations and extradimensional discriminations. Aripiprazole at 3 and 6 mg/kg did greatly mitigate the cognition deficits in comparison with placebo and 1 mg/kg of aripiprazole. Conclusion: The current study results emphasise the positive effect of aripiprazole on cognition. Aripiprazole has the potential to be a treatment for ADHD with a psychostimulatory effect.
Keywords
aripiprazole, ADHD, dopamine, social isolation, schizophrenia, psychostimulant