In vitro skin models. Challenges and future steps

Sophia Letsiou; Apostolos Beloukas; Efstathios Rallis; Vasiliki K. Kefala

doi:10.61873/FCXV3865

Review of Clinical Pharmacology and Pharmacokinetics – International Edition 38(s1): 63-65, doi: 10.61873/FCXV3865

In vitro skin models. Challenges and future steps

Sophia Letsiou^‡, Apostolos Beloukas^‡, Efstathios Rallis^‡, Vasiliki K. Kefala^‡

‡ Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, Ag. Spyridonos Str., Egaleo, 12243, Athens, Greece

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation: Letsiou S, Beloukas A, Rallis E, Kefala VK (2024) In vitro skin models. Challenges and future steps. Review of Clinical Pharmacology and Pharmacokinetics – International Edition 38(s1): 63-65. https://doi.org/10.61873/FCXV3865

Abstract

The in vitro models have great potential in skin-related research as well as in testing for active ingredients in cosmetics, dermocosmetics and pharmaceuticals. Human skin behavior can be simulated in vitro using a variety of methods ranging from cell monolayer models to complicated organotypic and bioengineered three-dimensional models. Moreover, skin in vitro models offer an excellent alternative to animal testing in cosmetics and some of them are validated to be used as preclinical assays. However, the in vitro simulation of the whole skin together with its appendages is still in its early stages. In this article we discuss a short evolution of skin models with its challenges and its future.

Keywords

in vitro models, skin models, three-dimensional models, cosmetics