Neonatal hypoglycemia is the most common metabolic disorder during the neonatal period. Despite its frequency of occurrence, there is no specific glucose concentration that defines it. Various symptoms and clinical manifestations characterize it, and its complications are related to its severity and duration. This review aims at comparing the recommendations of the American Academy of Pediatrics, the Pediatric Endocrine Society, and the Academy of Breastfeeding Medicine regarding the risk factors, the diagnosis, and the management of hypoglycemia. The complexity of hypoglycemia management and the research questions that need to be answered are highlighted by comparing the three guidelines. Preventing neonatal hypoglycemia by monitoring the maternal glucose concentrations, exploring and defining the optimal glycemic targets, investigating the long-term benefits after following these guidelines, and searching for less invasive diagnostic and therapeutic tools may help healthcare professionals make informed decisions to achieve better outcomes for these neonates.