Introduction: The role of health systems and hospital administrative system in Covid-19 pandemic period is of utmost importance. Objective: The scope of study is to assess the preparedness, response competencies of administrative staff and resilience of health system as well as to highlight the need of modernizing the role of the above three components. Methods: 175 executives from public hospitals of the seven Regional Health Authorities in Greece participated in an online survey. Demographic, occupational data were collected and presented with correlations of individual variables. Results: The mental working condition of staff became much worse. The 96,7% of participants believed that the country does not implement a pandemic preparedness plan while 83,3% think that this plan has not been updated. Also, 38.9% of participants had no idea whether the strengthening of health system resilience is a current preoccupation of health policy makers. Conclusions: Measures of new managements are considered necessary for a successful reform effort. The organization of health systems and development of medical countermeasures are suggested as essential for the preparedness and response of Healthcare Administrative Staff of the Public Hospitals as well as the resilience of Greek Health System.