143 urn:lsid:arphahub.com:pub:892805cc-c5d0-571f-8841-3ba335035073 Review of Clinical Pharmacology and Pharmacokinetics – International Edition RCPP 1011-6583 2945-1922 PHARMAKON-Press 10.61873/ILCP1133 34813 Research Article The impact of human albumin on the activity of some anti-staphylococcal agents in an in vitro pharmacokinetics / pharmacodynamics model Jihad Safa 1 2 Al-Saigh Rafal J. 3 Al-Humadi Hussam W. 4 Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Hillah, Iraq Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon Hillah Iraq Department of Pharmacology, College of Medicine, University of Babylon, Hillah, Iraq Department of Pharmacology, College of Medicine, University of Babylon Hillah Iraq Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Hillah, Iraq Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon Hillah Iraq College of Pharmacy, University of Babylon, Hillah, Iraq College of Pharmacy, University of Babylon Hillah Iraq

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2024 05 05 2024 38 s2 129 132 71924AB4-0294-53A5-A915-A7A9AFC41DF1 Safa Jihad, Rafal J. Al-Saigh, Hussam W. Al-Humadi This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The emergence of anti-staphylococcal drug resistance has significantly increased, thereby making it difficult to control the life-threatening staphylococcal infections. A validated two-compartment in vitro pharmacokinetics / pharmacodynamics (PK/PD) model has been used in order to estimate the efficacies of some anti-staphylococcal drugs – namely, vancomycin (maximum concentration or C max of 3 and 5 mg/L), teicoplanin (C max of 5 and 10 mg/L), and minocycline (C max of 2 and 4 mg/L) – against a mixed staphylococcal infection ( S. aureus ATCC 25923 and S. epidermidis ATCC 12228), with or without human albumin (2%). The PK profile for each drug was simulated as time-concentration depending on the drug’s half-life. The minimum inhibitory concentration (MIC), the relative optical density for bacterial growth, and the exposure / effect relationship (fAUC 0-24 /MIC) have also been assessed in this study. Our results revealed that minocycline has the best efficacy over other antibiotics against the assessed isolates (single or mixed). Moreover, the addition of albumin exhibited a negative effect on vancomycin and a positive effect on teicoplanin in both the single and the mixed infections. In conclusion, albumin drew a different antibiotic scenario in response to different pathogens.