143 urn:lsid:arphahub.com:pub:892805cc-c5d0-571f-8841-3ba335035073 Review of Clinical Pharmacology and Pharmacokinetics – International Edition RCPP 1011-6583 2945-1922 PHARMAKON-Press 10.61873/JMOB1139 34798 Research Article Cytotoxic effects of the Crassula ovata n-hexane fraction on human esophagus cancer KYSE-30 cells Al-Yassery Hawraa Kareem 1 khadim Enas 2 Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Babylon, Babylon, Iraq Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Babylon Babylon Iraq Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad, Baghdad, Iraq Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad Baghdad Iraq

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2024 05 05 2024 38 s2 97 100 D393EDA8-3E9F-5225-BC42-F53955E4D599 Hawraa Kareem Al-Yassery, Enas khadim This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The current study shows the cytotoxicity effect of the Crassula ovata n-hexane extract on esophagus cancer. C. ovata is a perennial succulent plant belonging to the Crassulaceae family. In Africa, the leaves were used medicinally to cure epilepsy and diarrhoea by boiling them in milk. The hexane fraction, which is obtained through the maceration method, demonstrates the presence of many compounds that have an anticancer effect, which are obtained by gas chromatography – mass spectroscopy. The phytosterol compound was isolated by a preparative thin layer chromatograph and was identified by liquid chromatography – mass spectroscopy. The hexane fraction was found to possess a strong anticancer effect against esophagus cancer. The obtained data from the human esophagus cancer KYSE-30 cell-line were analysed by one-way ANOVA, with a significance level of p <0.05.