143 urn:lsid:arphahub.com:pub:892805cc-c5d0-571f-8841-3ba335035073 Review of Clinical Pharmacology and Pharmacokinetics – International Edition RCPP 1011-6583 2945-1922 PHARMAKON-Press 10.61873/OJPV6764 34744 Research Article Antioxidant and antidiabetic potential of Acanthus mollis L. using choline chloride-based deep eutectic solvents Trapali Maria 1 Tebbi Sara Oumenoune 2 Karkalousos Petros 1 Debbache-Benaida Nadjet 2 Chaniotis Dimitrios https://orcid.org/0000-0003-2313-1305 1 Apostolopoulos Vasso 3 Laboratory of Chemistry Biochemistry and Cosmetic Science & Laboratory of Anatomy, Pathology and Physiology Nutrition, Department of Biomedical Sciences, University of West Attica, Egaleo, Athens, Greece Laboratory of Chemistry Biochemistry and Cosmetic Science & Laboratory of Anatomy, Pathology and Physiology Nutrition, Department of Biomedical Sciences, University of West Attica, Egaleo Athens Greece Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, Algeria Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia Bejaia Algeria Institute for Health and Sport, Victoria University, Werribee, Australia Institute for Health and Sport, Victoria University Werribee Australia

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2024 15 03 2024 38 1 19 25 8C5E688C-4EAF-53E6-AB93-5DAEBBD2F07C Maria Trapali, Sara Oumenoune Tebbi, Petros Karkalousos, Nadjet Debbache-Benaida, Dimitrios Chaniotis, Vasso Apostolopoulos This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

In recent years, the study of medicinal plants’ therapeutic properties has increased due to their effects and biological activities. The Acanthaceae family consists of 242 genera and 3947 species mainly distributed across tropical and subtropical zones. This family is known to contain a wide range of bioactive compounds, such as, alkaloids, triterpenes steroids glycosides, polyphenols, and polysaccharides. Herein, the antioxidant and anti-diabetic effects of Acanthus mollis (AM) extracted by green alternative technology; ultrasound assisted-deep eutectic solvents extraction (UAE-DES) were determined. The data obtained, showed that AM seeds had the highest Total Phenolic Content, antioxidant activity and anti-diabetic activity compared to AM seeds shell. The presence of antioxidants with anti-diabetic properties in AM could potentially serve as a foundation for innovative drug formulations capable of addressing several diseases. However, it is strongly advised that studies, including toxicity assessments, be conducted with a view towards pharmaceutical applications.