The in vitro models have great potential in skin-related research as well as in testing for active ingredients in cosmetics, dermocosmetics and pharmaceuticals. Human skin behavior can be simulated in vitro using a variety of methods ranging from cell monolayer models to complicated organotypic and bioengineered three-dimensional models. Moreover, skin in vitro models offer an excellent alternative to animal testing in cosmetics and some of them are validated to be used as preclinical assays. However, the in vitro simulation of the whole skin together with its appendages is still in its early stages. In this article we discuss a short evolution of skin models with its challenges and its future.