In the present paper we study the literature and research done by notable researchers, around the science of transdermal administration, the most recent scientific developments in enhancing skin permeability using third generation technologies. The purpose of this search is to find the latest transdermal methods through electrically assisted transdermal absorption systems to address aesthetic problems, specifically with the electroporation method. Electroporation allows quick and deep penetration of active ingredients, through the “electropores” promoting the ability to channel ingredients such as vitamins, minerals, amino acids, etc. to the desired point. In this way, effective, targeted, and uniform distribution of the active water-soluble substances of small and high molecular weight is achieved, in deeper layers of the skin tissues. As a result of this whole process, the electroporation method is an additional weapon in our quiver for dealing with and improving aesthetic problems.