This literature review article discusses the use of isotretinoin and examines its association with psychiatric adverse effects, particularly depression and suicidal ideation. The article presents historical and molecular data on isotretinoin and delves into the literature regarding its psychiatric side effects in the treatment of acne vulgaris. It tries to answer in questions about whether the scientific community has overlooked the significance of the underlying disease and explores the awareness of healthcare professionals regarding these potential adverse effects. Additionally, it investigates the likelihood of these effects based on the available literature to date.